Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation

被引：44

作者：

Chu, Pei-Yi ^{[1
]}

Hsu, Dur-Zong ^{[1
]}

Hsu, Pin-Yen ^{[1
]}

Liu, Ming-Yie ^{[1
,2
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70428, Taiwan

[2] Natl Cheng Kung Univ, Sustainable Environm Res Ctr, Tainan 70428, Taiwan

来源：

INNATE IMMUNITY | 2010年 / 16卷 / 05期

关键词：

inflammation; lipopolysaccharide; nuclear factor-kappa B; pro-inflammatory mediators; sesamol; TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; SYNERGISTIC INTERACTIONS; OXIDATIVE STRESS; CECAL LIGATION; SEVERE SEPSIS; INTERLEUKIN-1; CYTOKINE; TNF; EXPRESSION;

D O I：

10.1177/1753425909351880

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We examined the effects of sesamol on the lipopolysaccharide (LPS)-induced inflammatory response. Sesamol inhibited serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and nitrite production in LPS-treated mice, and inhibited LPS-induced inducible nitric oxide synthase expression in mouse leukocytes. Sesamol also down-regulated TNF-alpha, IL-1 beta, and nitrite production as well as inducible nitric oxide synthase expression in LPS-treated RAW 264.7 cells. Further, sesamol inhibited LPS-induced nuclear factor (NF)-kappa B translocation and inhibitor (I) kappa B-alpha phosphorylation in RAW 264.7 cells. By inhibiting TNF-alpha, IL-1 beta, and nitrite levels, and interfering with the NFkB kappa B pathway, sesamol down-regulated the LPS-initiated inflammatory response.

引用

页码：333 / 339

页数：7

共 30 条

[1]

NF-κB activation [J].

Abraham, E .

CRITICAL CARE MEDICINE, 2000, 28 (04) :N100-N104

[2]

The NF-kappa B and I kappa B proteins: New discoveries and insights [J].

Baldwin, AS .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683

[3]

Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: What we do and do not know about cytokine regulation [J].

Bone, RC .

CRITICAL CARE MEDICINE, 1996, 24 (01) :163-172

[4]

Increased survival after cecal ligation and puncture in mice consuming diets enriched with sesame seed oil [J].

Chavali, SR ;

Utsunomiya, T ;

Forse, RA .

CRITICAL CARE MEDICINE, 2001, 29 (01) :140-143

[5]

Tobacco smoking inhibits expression of proinflammatory Cytokines and activation of IL-1R-Associated kinase, p38, and NF-κB in alveolar macrophages stimulated with TLR2 and TLR4 Agonists [J].

Chen, Haiyan ;

Cowan, Mark J. ;

Hasday, Jeffrey D. ;

Vogel, Stefanie N. ;

Medvedev, Andrei E. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (09) :6097-6106

[6]

Effect of a chimeric antibody to tumor necrosis factor-α on cytokine and physiologic responses in patients with severe sepsis -: A randomized, clinical trial [J].

Clark, MA ;

Plank, LD ;

Connolly, AB ;

Streat, SJ ;

Hill, AA ;

Gupta, R ;

Monk, DN ;

Shenkin, A ;

Hill, GL .

CRITICAL CARE MEDICINE, 1998, 26 (10) :1650-1659

[7]

Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein [J].

Fisher, CJ ;

Agosti, JM ;

Opal, SM ;

Lowry, SF ;

Balk, RA ;

Sadoff, JC ;

Abraham, E ;

Schein, RMH ;

Benjamin, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (26) :1697-1702

[8]

INFUSION OF TUMOR NECROSIS FACTOR CACHECTIN PROMOTES MUSCLE CATABOLISM IN THE RAT - A SYNERGISTIC EFFECT WITH INTERLEUKIN-1 [J].

FLORES, EA ;

BISTRIAN, BR ;

POMPOSELLI, JJ ;

DINARELLO, CA ;

BLACKBURN, GL ;

ISTFAN, NW .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (05) :1614-1622

[9]

NF-κB and rel proteins:: Evolutionarily conserved mediators of immune responses [J].

Ghosh, S ;

May, MJ ;

Kopp, EB .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :225-260

[10]

NITRATE BIOSYNTHESIS IN MAN [J].

GREEN, LC ;

DELUZURIAGA, KR ;

WAGNER, DA ;

RAND, W ;

ISTFAN, N ;

YOUNG, VR ;

TANNENBAUM, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7764-7768

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