ABP1 Mediates Auxin Inhibition of Clathrin-Dependent Endocytosis in Arabidopsis

被引：326

作者：

Robert, Stephanie ^{[1
,2
]}

Kleine-Vehn, Juergen ^{[1
,2
]}

Barbez, Elke ^{[1
,2
]}

Sauer, Michael ^{[1
,2
]}

Paciorek, Tomasz ^{[1
,2
]}

Baster, Pawel ^{[1
,2
]}

Vanneste, Steffen ^{[1
,2
]}

Zhang, Jing ^{[1
,2
]}

Simon, Sibu ^{[3
]}

Covanova, Milada ^{[3
]}

Hayashi, Kenichiro ^{[4
]}

Dhonukshe, Pankaj ^{[5
]}

Yang, Zhenbiao ^{[6
,7
]}

Bednarek, Sebastian Y. ^{[8
]}

Jones, Alan M. ^{[9
,10
]}

Luschnig, Christian ^{[11
]}

Aniento, Fernando ^{[12
]}

Zazimalova, Eva ^{[3
]}

Friml, Jiri ^{[1
,2
]}

机构：

[1] VIB, Dept Plant Syst Biol, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Plant Biotechnol & Genet, B-9052 Ghent, Belgium

[3] ASCR, Inst Expt Bot, Prague 16502 6, Czech Republic

[4] Okayama Univ Sci, Dept Biochem, Okayama 7000005, Japan

[5] Univ Utrecht, Dept Biol, NL-3584 CH Utrecht, Netherlands

[6] Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA

[7] Univ Calif Riverside, Ctr Plant Cell Biol, Inst Integrat Genome Biol, Riverside, CA 92521 USA

[8] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[9] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[10] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[11] Univ Nat Resources & Appl Life Sci, BOKU, Inst Appl Genet & Cell Biol, A-1190 Vienna, Austria

[12] Univ Valencia, Dept Bioquim & Biol Mol, Burjassot 46100, Spain

来源：

CELL | 2010年 / 143卷 / 01期

基金：

美国国家科学基金会;

关键词：

OF-FUNCTION MUTATION; BOX PROTEIN TIR1; BINDING PROTEIN-1; CELL EXPANSION; ENDOPLASMIC-RETICULUM; TRANSFERRIN RECEPTOR; PLASMA-MEMBRANE; EFFLUX CARRIER; TYRPHOSTIN A23; TRANSPORT;

D O I：

10.1016/j.cell.2010.09.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spatial distribution of the plant hormone auxin regulates multiple aspects of plant development. These self-regulating auxin gradients are established by the action of PIN auxin transporters, whose activity is regulated by their constitutive cycling between the plasma membrane and endosomes. Here, we show that auxin signaling by the auxin receptor AUXIN-BINDING PROTEIN 1 (ABP1) inhibits the clathrin-mediated internalization of PIN proteins. ABP1 acts as a positive factor in clathrin recruitment to the plasma membrane, thereby promoting endocytosis. Auxin binding to ABP1 interferes with this action and leads to the inhibition of clathrin-mediated endocytosis. Our study demonstrates that ABP1 mediates a nontranscriptional auxin signaling that regulates the evolutionarily conserved process of clathrin-mediated endocytosis and suggests that this signaling may be essential for the developmentally important feedback of auxin on its own transport.

引用

页码：111 / 121

页数：11

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