Cytokine production and modulation: Comparison of patients with chronic fatigue syndrome and normal controls

被引：48

作者：

Tomoda, A ^{[1
]}

Joudoi, T ^{[1
]}

El-Mezayen Rabab ^{[1
]}

Matsumoto, T ^{[1
]}

Park, TH ^{[1
]}

Miike, T ^{[1
]}

机构：

[1] Kumamoto Univ, Sch Med, Dept Child Dev, Kumamoto 860, Japan

来源：

PSYCHIATRY RESEARCH | 2005年 / 134卷 / 01期

关键词：

chronic fatigue syndrome (CFS); cytokines; transforming growth factor-beta1 (TGF-ss 1); peripheral blood mononuclear cells (PBMC);

D O I：

10.1016/j.psychres.2005.01.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 [精神病与精神卫生学];

摘要：

We studied cytokine production in 15 patients with chronic fatigue syndrome (CFS) and 23 controls. CFS patients' peripheral blood mononuclear cells were cultured with lipopolysaccharide or phytohemagglutinin. Enzymatic immunoassay indicated cytokine concentration in culture supernatants. CFS patients showed significantly lower mRNA levels and transforming growth factor-betal (TGF-beta 1) production. Cytokine dysregulation affects CFS pathogenesis. TGF-beta 1 may aid treatment because it affects CFS inflammatory characteristics. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：101 / 104

页数：4

共 19 条

[1]

POSTVIRAL FATIGUE SYNDROME - PERSISTENCE OF ENTEROVIRUS RNA IN MUSCLE AND ELEVATED CREATINE-KINASE [J].

ARCHARD, LC ;

BOWLES, NE ;

BEHAN, PO ;

BELL, EJ ;

DOYLE, D .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1988, 81 (06) :326-329

[2]

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome [J].

Bennett, AL ;

Chao, CC ;

Hu, SX ;

Buchwald, D ;

Fagioli, LR ;

Schur, PH ;

Peterson, PK ;

Komaroff, AL .

JOURNAL OF CLINICAL IMMUNOLOGY, 1997, 17 (02) :160-166

[3]

Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables [J].

Borish, L ;

Schmaling, K ;

DiClementi, JD ;

Streib, J ;

Negri, J ;

Jones, JF .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 102 (02) :222-230

[4]

A TRANSFORMING-GROWTH-FACTOR-BETA-LIKE IMMUNOSUPPRESSIVE FACTOR IN IMMUNOGLOBULIN-G-BINDING FACTOR [J].

BOUCHARD, C ;

GALINHA, A ;

TARTOUR, E ;

FRIDMAN, WH ;

SAUTES, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1717-1726

[5]

ALTERED CYTOKINE RELEASE IN PERIPHERAL-BLOOD MONONUCLEAR CELL-CULTURES FROM PATIENTS WITH THE CHRONIC FATIGUE SYNDROME [J].

CHAO, CC ;

JANOFF, EN ;

HU, SX ;

THOMAS, K ;

GALLAGHER, M ;

TSANG, M ;

PETERSON, PK .

CYTOKINE, 1991, 3 (04) :292-298

[6]

INTERLEUKIN-10 (IL-10) INHIBITS HUMAN LYMPHOCYTE INTERFERON GAMMA-PRODUCTION BY SUPPRESSING NATURAL-KILLER-CELL STIMULATORY FACTOR/IL-12 SYNTHESIS IN ACCESSORY CELLS [J].

DANDREA, A ;

ASTEAMEZAGA, M ;

VALIANTE, NM ;

MA, XJ ;

KUBIN, M ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :1041-1048

[7]

TRANSFORMING GROWTH-FACTOR-BETA AND SUPPRESSION OF HUMORAL IMMUNE-RESPONSES IN HIV-INFECTION [J].

KEKOW, J ;

WACHSMAN, W ;

MCCUTCHAN, JA ;

GROSS, WL ;

ZACHARIAH, M ;

CARSON, DA ;

LOTZ, M .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (03) :1010-1016

[8]

CHRONIC FATIGUE SYNDROMES - RELATIONSHIP TO CHRONIC VIRAL-INFECTIONS [J].

KOMAROFF, AL .

JOURNAL OF VIROLOGICAL METHODS, 1988, 21 (1-4) :3-10

[9]

KOMAROFF AL, 1991, REV INFECT DIS S1, V13, P8

[10]

VIRAL STUDIES OF CHRONIC FATIGUE SYNDROME .3. INTRODUCTION [J].

LEVY, JA .

CLINICAL INFECTIOUS DISEASES, 1994, 18 :S117-S120

← 1 2 →