Landmark detection in the chest and registration of lung surfaces with an application to nodule registration

被引:100
作者
Betke, M
Hong, H
Thomas, D
Prince, C
Ko, JP
机构
[1] Boston Univ, Dept Comp Sci, Boston, MA 02215 USA
[2] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA
基金
美国国家科学基金会;
关键词
computed tomography; chest; lung surfaces; nodule registration;
D O I
10.1016/S1361-8415(03)00007-0
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
We developed an automated system for registering computed tomography (CT) images of the chest temporally. Our system detects anatomical landmarks, in particular, the trachea, sternum and spine, using an attenuation-based template matching approach. It computes the optimal rigid-body transformation that aligns the corresponding landmarks in two CT scans of the same patient. This transformation then provides an initial registration of the lung surfaces segmented from the two scans. The initial surface alignment is refined step by step in an iterative closest-point (ICP) process. To establish the correspondence of lung surface points, Elias' nearest neighbor algorithm was adopted. Our method improves the processing time of the original ICP algorithm from O(kn log n) to O(kn), where k is the number of iterations and n the number of surface points. The surface transformation is applied to align nodules in the initial CT scan with nodules in the follow-up scan. For 56 out of 58 nodules in the initial CT scans of 10 patients, nodule correspondences in the follow-up scans are established correctly. Our methods can therefore potentially facilitate the radiologist's evaluation of pulmonary nodules on chest CT for interval growth. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:265 / 281
页数:17
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