Cyclooxygenase enzymes in allergic inflammation and asthma

被引：58

作者：

Carey, MA ^{[1
]}

Germolec, DR ^{[1
]}

Langenbach, R ^{[1
]}

Zeldin, DC ^{[1
]}

机构：

[1] NIEHS, Div Intramural Res, NIH, Res Triangle Pk, NC 27709 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2003年 / 69卷 / 2-3期

关键词：

D O I：

10.1016/S0952-3278(03)00076-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cyclooxygenase enzyme system produces eicosanoids which mediate many important physiological and pathological functions. Experimental and clinical data suggest a role for this enzyme system in the pathogenesis of allergic inflammation and asthma. This article focuses on the function of this pathway in the lung, reviews evidence implicating the involvement of this pathway in asthma and allergic airway inflammation, and discusses implications for the treatment of asthmatics with cyclooxygenase inhibitors. Published by Elsevier Science Ltd.

引用

页码：157 / 162

页数：6

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