Transferrin and prolactin transcytosis in the lactating mammary epithelial cell

被引:36
作者
Ollivier-Bousquet, M [1 ]
机构
[1] INRA, Biol Cellulaire & Mol Lab, F-78352 Jouy En Josas, France
关键词
transcytosis; transferrin; prolactin; endocytosis; mammary epithelial cell;
D O I
10.1023/A:1018767528017
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The mammary epithelial cell ferries constituents originating from blood and from stromal cells, into milk, by transcytosis. Morphological analysis of a membrane marker of transcytosis in the lactating mammary epithelial cell showed that very rapid endocytosis of surface membrane occurs from both the basolateral and the apical side of the cell. In both cases, membrane trafficking between endosomes and the Golgi complex allows communication between the endocytic and the biosynthetic pathways. Transferrin and prolactin are internalized in mammary cells and transported through multivesicular bodies and Golgi stacks. They are released into milk via different types of secretory vesicles, prolactin being carried in secretory vesicles containing casein micelles. Consequences of the intracellular transport of these proteins and physiological benefits for cell function are discussed.
引用
收藏
页码:303 / 313
页数:11
相关论文
共 53 条
[1]   ROLE OF MILK SECRETION IN TRANSPORT OF PROLACTIN FROM BLOOD INTO MILK [J].
AKERS, RM ;
KAPLAN, RM .
HORMONE AND METABOLIC RESEARCH, 1989, 21 (07) :362-365
[2]   EFFECT OF COLCHICINE ON INTERNALIZATION OF PROLACTIN IN FEMALE RAT-LIVER - AN INVIVO AUTORADIOGRAPHIC STUDY [J].
BERGERON, JJM ;
RESCH, L ;
RACHUBINSKI, R ;
PATEL, BA ;
POSNER, BI .
JOURNAL OF CELL BIOLOGY, 1983, 96 (03) :875-886
[3]   Intracellular signal transduction: The role of endosomes [J].
Bevan, AP ;
Drake, PG ;
Bergeron, JJM ;
Posner, BI .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1996, 7 (01) :13-21
[4]   ARACHIDONIC-ACID METABOLISM AND CASEIN SECRETION IN LACTATING RABBIT MAMMARY EPITHELIAL-CELLS - EFFECTS OF INHIBITORS OF PROSTAGLANDINS AND LEUKOTRIENES SYNTHESIS [J].
BLACHIER, F ;
LACROIX, MC ;
AHMED, AM ;
LEGER, C ;
OLLIVIERBOUSQUET, M .
PROSTAGLANDINS, 1988, 35 (02) :259-276
[5]   CLONING AND EXPRESSION OF THE RAT PROLACTIN RECEPTOR, A MEMBER OF THE GROWTH-HORMONE PROLACTIN RECEPTOR GENE FAMILY [J].
BOUTIN, JM ;
JOLICOEUR, C ;
OKAMURA, H ;
GAGNON, J ;
EDERY, M ;
SHIROTA, M ;
BANVILLE, D ;
DUSANTERFOURT, I ;
DJIANE, J ;
KELLY, PA .
CELL, 1988, 53 (01) :69-77
[6]   THE BIOLOGY OF TRANSFERRIN [J].
DEJONG, G ;
VANDIJK, JP ;
VANEIJK, HG .
CLINICA CHIMICA ACTA, 1990, 190 (1-2) :1-46
[7]   Milk-Borne Prolactin and Neonatal Development [J].
Ellis, Lorie A. ;
Mastro, Andrea M. ;
Picciano, Mary Frances .
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1996, 1 (03) :259-269
[8]   BLOOD PROLACTIN CONCENTRATIONS AFFECT PROLACTIN TRANSFER INTO GOAT MILK - IMPLICATIONS FOR MAINTENANCE OF LACTATION [J].
FORSYTH, IA ;
TAYLOR, JA ;
GABAI, G ;
FLEET, IR .
JOURNAL OF ENDOCRINOLOGY, 1995, 146 (03) :411-420
[9]   INVOLVEMENT OF VESICLE COAT MATERIAL IN CASEIN SECRETION AND SURFACE REGENERATION [J].
FRANKE, WW ;
LUDER, MR ;
KARTENBECK, J ;
ZERBAN, H ;
KEENAN, TW .
JOURNAL OF CELL BIOLOGY, 1976, 69 (01) :173-195
[10]   ENDOCYTOSIS AND DEGRADATION OF PROLACTIN AND ITS RECEPTOR IN CHINESE-HAMSTER OVARY CELLS STABLY TRANSFECTED WITH PROLACTIN RECEPTOR CDNA [J].
GENTY, N ;
PALY, J ;
EDERY, M ;
KELLY, PA ;
DJIANE, J ;
SALESSE, R .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1994, 99 (02) :221-228