Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias

被引：192

作者：

Okamoto, M. ^{[1
]}

Hoshino, T. ^{[1
]}

Kitasato, Y. ^{[1
]}

Sakazaki, Y. ^{[1
]}

Kawayama, T. ^{[1
]}

Fujimoto, K. ^{[2
]}

Ohshima, K. ^{[3
]}

Shiraishi, H. ^{[4
]}

Uchida, M. ^{[4
]}

Ono, J. ^{[6
]}

Ohta, S. ^{[5
]}

Kato, S. ^{[7
,8
]}

Izuhara, K. ^{[4
,5
]}

Aizawa, H. ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Div Respirol Neurol & Rheumatol, Dept Med, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Div Respirol Neurol & Rheumatol, Dept Radiol, Kurume, Fukuoka 8300011, Japan

[3] Kurume Univ, Sch Med, Div Respirol Neurol & Rheumatol, Dept Pathol, Kurume, Fukuoka 8300011, Japan

[4] Saga Med Sch, Div Med Biochem, Dept Biomol Sci, Saga, Japan

[5] Saga Med Sch, Div Med Biochem, Dept Lab Med, Saga, Japan

[6] Shino Test Corp, Tokyo, Japan

[7] Univ Ryukyus, Grad Sch, Div Pathol & Cell Biol, Okinawa, Japan

[8] Univ Ryukyus, Fac Med, Okinawa, Japan

来源：

EUROPEAN RESPIRATORY JOURNAL | 2011年 / 37卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

Biomarker; idiopathic pulmonary fibrosis; lung fibrosis; matrix protein; usual interstitial pneumonia; PULMONARY-FIBROSIS; LUNG-DISEASE; PROGNOSTIC VALUE; CLASSIFICATION; INTERLEUKIN-18; EXPRESSION; BIOPSY; SERA;

D O I：

10.1183/09031936.00059810

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Idiopathic interstitial pneumonias (IIPs) are histopathologically classified into several types, including usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP) and cryptogenic organising pneumonia (COP). We investigated whether periostin, a matrix protein, could be used as a biomarker to assess histopathological types of IIPs. We performed immunohistochemical analyses in each histopathological type of IIP, examined serum levels of periostin in IIP patients and analysed the relationship between serum levels of periostin and the pulmonary functions in patients with idiopathic pulmonary fibrosis (IPF). Periostin was strongly expressed in lungs of UIP and fibrotic NSIP patients, whereas expression of periostin was weak in the lungs of cellular NSIP and COP patients, as well as in normal lungs. Serum levels of periostin in IPF were significantly higher than those of healthy subjects and COP patients. Furthermore, periostin levels in IPF patients were inversely correlated with their pulmonary functions. Thus, we have found that periostin is a novel component of fibrosis in IIP. Periostin may be a potential biomarker to distinguish IIP with fibrosis.

引用

页码：1119 / 1127

页数：9

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