Cyclophosphamide in the treatment of toxic epidermal necrolysis

被引：50

作者：

Frangogiannis, NG ^{[1
]}

Boridy, I ^{[1
]}

Mazhar, M ^{[1
]}

Mathews, R ^{[1
]}

Gangopadhyay, S ^{[1
]}

Cate, T ^{[1
]}

机构：

[1] BEN TAUB GEN HOSP, HOUSTON, TX 77030 USA

来源：

SOUTHERN MEDICAL JOURNAL | 1996年 / 89卷 / 10期

关键词：

D O I：

10.1097/00007611-199610000-00015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with non-small cell lung carcinoma and recent radiotherapy for brain metastases developed toxic epidermal necrolysis (TEN) shortly after therapy with phenytoin was initiated for a seizure. Exfoliation progressed to involve 90% of her body surface despite treatment with high-dose corticosteroids for 5 days, but sloughing and systemic toxicity ceased within 2 days of initiating therapy with intravenous cyclophosphamide (300 mg/day). Reepithelialization rapidly followed, This experience and the reports of others suggest that intravenous cyclophosphamide is helpful in the treatment of TEN.

引用

页码：1001 / 1003

页数：3

共 19 条

[1] ERYTHEMA MULTIFORME AND STEVENS-JOHNSON SYNDROME IN PATIENTS RECEIVING CRANIAL IRRADIATION AND PHENYTOIN [J].