Novel pharmacological strategies in amyloidosis

被引:8
作者
Lachmann, HJ [1 ]
Hawkins, PN [1 ]
机构
[1] UCL Royal Free Hosp, Dept Med, Natl Amyloidosis Ctr, Royal Free & Univ Coll Med Sch, London NW3 2QG, England
来源
NEPHRON CLINICAL PRACTICE | 2003年 / 94卷 / 04期
关键词
amyloid; amyloidosis; pharmacological strategies; serum amyloid P component; P-COMPONENT; DISEASE;
D O I
10.1159/000072490
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Amyloidosis is a disorder of protein folding in which normally soluble plasma proteins are deposited as insoluble fibrils that disrupt tissue structure. Over 20 unrelated proteins form amyloid in vivo, with fibrils sharing a cross-beta-sheet structure composed of non-covalently associated protein or peptide subunits. Glycosaminoglycans and serum amyloid P component are universal non-fibrillar constituents of amyloid, contributing to fibrillogenesis and the stability of amyloid deposits. Amyloidosis may be acquired or hereditary and local or systemic, and is classified according to the precursor protein. Current treatment consists of support or replacement of impaired organ function and measures to reduce the production of amyloidogenic precursor proteins. Potential novel therapeutic strategies include stabilisation of the native fold of precursor proteins, reversion of misfolded proteins to their native state, inhibition of fibril propagation and enhancement of amyloid clearance either through immunotherapy or by reducing the stability of deposits through depletion of serum amyloid P component. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码:C85 / C88
页数:4
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