Fibrosis in alcoholic and nonalcoholic steatohepatitis

被引：67

作者：

Bataller, Ramon ^{[1
,2
]}

Rombouts, Krista ^{[3
,4
]}

Altamirano, Jose ^{[1
,2
]}

Marra, Fabio ^{[3
,4
]}

机构：

[1] Hosp Clin Barcelona, Liver Unit, IDIBAPS, Barcelona 08015, Catalonia, Spain

[2] CIBERehd, Barcelona, Catalonia, Spain

[3] Univ Florence, Dipartimento Med Interna, I-50121 Florence, Italy

[4] Univ Florence, Ctr Res Transfer & Higher Educ DenoTHE, I-50121 Florence, Italy

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2011年 / 25卷 / 02期

关键词：

Fatty liver; Hepatic stellate cells; Kupffer cells; Cytokines; Chemokines; Adipokines; Elastography; Serum markers; Cirrhosis; Alcoholic hepatitis; FATTY LIVER-DISEASE; SCORING SYSTEM; GENETIC PREDISPOSITION; CRYPTOGENIC CIRRHOSIS; MOLECULAR-MECHANISMS; RISK-FACTOR; LEPTIN; PROGRESSION; MARKERS; NAFLD;

D O I：

10.1016/j.bpg.2011.02.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Both alcoholic and nonalcoholic steatohepatitis are relevant causes of cirrhosis and liver-related mortality. Alcohol abuse represents a major health problem in many countries, and liver disease is considered one of the most relevant causes of death related to this factor. Nonalcoholic fatty liver disease is the most common hepatic abnormality in the Western world, and progresses to cirrhosis and hepatocellular carcinoma in a significant portion of cases. Moreover, presence of NAFLD is associated with an increased risk of cardiovascular events. In this review, we discuss the characteristics of fibrosis in alcoholic and nonalcoholic steatohepatitis, focussing on the diagnostic issues and predictive factors. In addition, the patho-genetic mechanisms responsible for appearance and progression of fibrosis in the two conditions are briefly discussed. (C) 2011 Published by Elsevier Ltd.

引用

页码：231 / 244

页数：14

共 81 条

[1] THE AMOUNT OF ALCOHOL CONSUMPTION NEGATIVELY IMPACTS SHORT-TERM MORTALITY IN PATIENTS WITH ALCOHOLIC HEPATITIS: CLINICAL IMPLICATIONS [J].