Prognostic significance of increased serum bilirubin levels coincident with cardiac decompensation in chronic heart failure

Background The aim of this study was to analyze the relationship between abnormal liver function tests (LF-fs) coincident with heart failure (HF) exacerbation and subsequent long-term outcome in patients with chronic HF. Methods and Results The study population consisted of 183 consecutive patients admitted for HF exacerbation with left ventricular ejection fraction <= 40%. Cox proportional hazard analysis revealed that serum total bilirubin (T-Bil) levels on admission (hazard ratio 1.896, p<0.001, 95% confidence interval 1.323-2.717), but not T-Bil at discharge or other LFTs, was an independent predictor of subsequent cardiac events after hospital discharge (cardiac death or readmission for HF exacerbation) The cardiac-event-free rates significantly decreased according to increasing tertiles of T-Bil stratified by the level of 0.7 and 1.2mg/dl (p<0.001). T-Bil on admission had significant correlations with simultaneously-measured central venous pressure (CVP) (r=0.42, p<0.01) and cardiac index (CI) (r=-0.50, p<0.01). The patients demonstrating high CVP together with low CI showed significantly increased T-Bil compared with any other group. Conclusions Increased T-Bil coincident with cardiac decompensation predicts a worse long-term, prognosis of CHF, presumably through the potential liability to both congestion and tissue hypoperfusion simultaneously when HF deteriorates.