Carbonylation of 2-chloro-4,6-dimethoxypyrimidine and 2-(chloromethyl)-4,6-dimethoxypyrimidine

被引：8

作者：

Bessard, Y ^{[1
]}

Crettaz, R ^{[1
]}

机构：

[1] LONZA LTD, Dept Proc Res, CH-3930 Visp, Switzerland

来源：

TETRAHEDRON | 1999年 / 55卷 / 02期

关键词：

carbonylation reactions; carboxylic acid esters; heck type reactions; pyrimidines;

D O I：

10.1016/S0040-4020(98)01038-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of pyrimidine-2-carboxylates and 2-pyrimidineacetates by alkoxycarbonylation of respectively 2-chloropyrimidine and 2-(chloromethyl)pyrimidine with carbon monoxide in the presence of palladium acetate and 1,1'-bis(diphenylphosphino)ferrocene is described. The new process uses readily available starting materials and affords the corresponding esters in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：405 / 412

页数：8