Synthesis of novel peptidomimetics, cyclic hexamers of unnatural amino acids, 2,5-disubstituted 3-aminobenzoic acids

被引：5

作者：

Endo, K ^{[1
]}

Takahashi, H ^{[1
]}

机构：

[1] Tohoku Coll Pharm, Aoba Ku, Sendai, Miyagi 9818558, Japan

来源：

HETEROCYCLES | 1999年 / 51卷 / 02期

关键词：

D O I：

10.3987/COM-98-8445

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Coupling of 3-aminobenzoic acids and cyclization of their peptides have been accomplished, for the first time, using methanesulfonyl chloride. Cylindrical conformations for the 30-membered cyclic hexapeptides, with trans configuration at the amide bonds, are suggested by ROESY study as well as MM calculations.

引用

页码：337 / 344

页数：8

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[4]

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[9]

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