Precision Synthesis of Biodegradable Polymers

被引：89

作者：

Thomas, Christophe M. ^{[1
]}

Lutz, Jean-Francois ^{[2
]}

机构：

[1] Chim ParisTech, UMR CNRS 7223, F-75005 Paris, France

[2] Inst Charles Sadron, CNRS UPR22, F-67034 Strasbourg, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 40期

基金：

欧洲研究理事会;

关键词：

biocompatible materials; biodegradable polymers; polymerization; polymers; primary structure; POLY(LACTIC ACID); SEQUENCE; DRUG; DEGRADATION; DELIVERY; POLYMERIZATION; NANOPARTICLES; CHEMISTRY; BEHAVIOR;

D O I：

10.1002/anie.201103076

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Its all in the sequence: The primary structure of poly(lactic-co-glycolic acid) (PLGA), a member of the most widely used class of biodegradable polymers employed in biomedical applications, is demonstrated to strongly influence its degradation properties. Experimental studies evidenced the beneficial effect of ordered monomer sequences on the material properties (see picture). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9244 / 9246

页数：3

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