Association of type 1 diabetes mellitus and epilepsy in children. A cohort of 10 cases

被引：7

作者：

Caietta, E. ^{[1
]}

Halbert, C. ^{[1
]}

Lepine, A. ^{[1
,2
,3
]}

Khammar, A. ^{[4
]}

Cano, A. ^{[1
]}

Gavaret, M. ^{[3
,5
]}

Mancini, J. ^{[1
,3
]}

Villeneuve, N. ^{[1
,2
,3
]}

Chabrol, B. ^{[1
,3
]}

Simonin, G. ^{[4
]}

Reynaud, R. ^{[4
]}

Milh, M. ^{[1
,2
,3
]}

机构：

[1] CHU La Timone, Serv Neurol Pediat, Assistance Publ Hop Marseille, F-13005 Marseille, France

[2] Hop Henri Gastaut, F-13009 Marseille, France

[3] Cinapse, Marseille, France

[4] CHU La Timone, Serv Pediat Multidisciplinaire, Assistance Publ Hop Marseille, F-13005 Marseille, France

[5] CHU La Timone, Serv Neurophysiol, Assistance Publ Hop Marseille, F-13005 Marseille, France

来源：

ARCHIVES DE PEDIATRIE | 2012年 / 19卷 / 01期

关键词：

GLUTAMIC-ACID-DECARBOXYLASE; AUTOANTIBODIES; CLASSIFICATION; ANTIBODIES; SEIZURES;

D O I：

10.1016/j.arcped.2011.10.010

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

The association of type 1 diabetes mellitus (DM) and epilepsy has been previously reported. However, the physiopathology of this association remains misunderstood. Objective. To describe epilepsy combined with type 1 DM in children. Methods. Retrospective monocentric study of all the epileptic and type 1 diabetic children consulting at the Timone University Hospital, Marseille, France. For each patient, the type of epilepsy and its electroclinical and radiographic characteristics were studied as well as the type of diabetes (biological characteristics, glycemic control), and the onset of these 2 diseases. Results. Ten patients are reported. Five suffered from generalized epilepsy (4 idiopathic, 1 nonidiopathic) and 5 from focal epilepsy (4 non-idiopathic, 1 idiopathic). For most of these cases, presence of GAD (glutamic acid decarboxylase) autoantibodies were confirmed and epilepsy followed diabetes. Conclusions. The 2 most common types of epilepsy in this association are idiopathic generalized epilepsy and non-idiopathic temporal epilepsy. Several mechanisms could he involved (immune, glycemia, and genetic disorders). (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：9 / 16

页数：8

共 22 条

[1]

The growing incidence of type 1 diabetes in children: The 17-year French experience in Aquitaine [J].

Barat, P. ;

Valade, A. ;

Brosselin, P. ;

Alberti, C. ;

Maurice-Tison, S. ;

Levy-Marchal, C. .

DIABETES & METABOLISM, 2008, 34 (06) :601-605

[2]

BAXTER CF, 1958, J BIOL CHEM, V233, P1135

[3]

Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009 [J].

Berg, Anne T. ;

Berkovic, Samuel F. ;

Brodie, Martin J. ;

Buchhalter, Jeffrey ;

Cross, J. Helen ;

Boas, Walter van Emde ;

Engel, Jerome ;

French, Jacqueline ;

Glauser, Tracy A. ;

Mathern, Gary W. ;

Moshe, Solomon L. ;

Nordli, Douglas ;

Plouin, Perrine ;

Scheffer, Ingrid E. .

EPILEPSIA, 2010, 51 (04) :676-685

[4]

Incidence data of childhood-onset type I diabetes in France during 1988-1997:: The case for a shift toward younger age at onset [J].

Charkaluk, ML ;

Czernichow, P ;

Lévy-Marchal, C .

PEDIATRIC RESEARCH, 2002, 52 (06) :859-862

[5]

Definition, epidemiology and classification of diabetes in children and adolescents [J].

Craig, Maria E. ;

Hattersley, Andrew ;

Donaghue, Kim C. .

PEDIATRIC DIABETES, 2009, 10 :3-12

[6]

Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: A study on 233 patients [J].

Errichiello, Luca ;

Perruolo, Giuseppe ;

Pascarella, Angelo ;

Formisano, Pietro ;

Minetti, Carlo ;

Striano, Salvatore ;

Zara, Federico ;

Striano, Pasquale .

JOURNAL OF NEUROIMMUNOLOGY, 2009, 211 (1-2) :120-123

[7]

Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies [J].

Giometto, B ;

Nicolao, P ;

Macucci, M ;

Tavolato, B ;

Foxon, R ;

Bottazzo, GF .

LANCET, 1998, 352 (9126) :457-457

[8]

Stiff-person syndrome and other neurological disorders associated with anti-GAD antibodies [J].

Hijazi, J. ;

Bedat-Millet, A. -L. ;

Hannequin, D. .

REVUE DE MEDECINE INTERNE, 2010, 31 (01) :23-28

[9]

Diabetic hyperglycemia is associated with the severity of epileptic seizures in adults [J].

Huang, Chin-Wei ;

Tsai, Jing-Jane ;

Ou, Horng-Yih ;

Wang, Shin-Tair ;

Cheng, Juei-Tang ;

Wu, Sheng-Nan ;

Huang, Chao-Ching .

EPILEPSY RESEARCH, 2008, 79 (01) :71-77

[10]

Jallon P, 2000, MED THER PEDIAT, V4, P10

← 1 2 3 →