Hairless triggers reactivation of hair growth by promoting Wnt signaling

被引：106

作者：

Beaudoin, GMJ

Sisk, JM

Coulombe, PA

Thompson, CC

机构：

[1] Johns Hopkins Univ, Sch Med, Kennedy Krieger Res Inst, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 41期

关键词：

corepressor; nuclear receptor; skin;

D O I：

10.1073/pnas.0507609102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mammalian hair cycle involves periodic regeneration of a tiny organ, the hair follicle, through a stem-cell-mediated process. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for hair follicle regeneration, but its role in this process is unknown. Here, we demonstrate that transgenic expression of HR in progenitor keratinocytes rescues follicle regeneration in Hr(-/-) mice. We show that expression of Wise, a modulator of Writ signaling, is repressed by HR in these cells, coincident with the timing of follicle regeneration. This work links HR and Writ function, providing a model in which HR regulates the precise timing of Wnt signaling required for hair follicle regeneration.

引用

页码：14653 / 14658

页数：6

共 45 条

[1] Alopecia universalis associated with a mutation in the human hairless gene [J].