Procedure for minimizing stress for fMRI studies in conscious rats

被引：176

作者：

King, JA ^{[1
]}

Garelick, TS ^{[1
]}

Brevard, ME ^{[1
]}

Chen, W ^{[1
]}

Messenger, TL ^{[1
]}

Duong, TQ ^{[1
]}

Ferris, CF ^{[1
]}

机构：

[1] Univ Massachusetts, Med Ctr, Dept Psychiat, Ctr Comparat Neuroimaging, Worcester, MA 01655 USA

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2005年 / 148卷 / 02期

关键词：

restraint stress; heart rate; imaging; blood pressure; HPA axis; fMRI;

D O I：

10.1016/j.jneumeth.2005.04.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional magnetic resonance imaging (fMRI) in conscious animals is evolving as a critical tool for neuroscientists. The present study explored the effectiveness of an acclimation procedure in minimizing the stress experienced by the animal as assessed by alterations in physiological parameters including heart rate, respiratory rate, and serum corticosterone levels. Results confirm that as the stress of the protocol is minimized, there is a significant decrease in head movements and enhancement in data quality. The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：154 / 160

页数：7

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