Interfacing Carbon Nanotubes with Living Mammalian Cells and Cytotoxicity Issues

被引:120
作者
Cui, Hui-Fang [2 ]
Vashist, Sandeep Kumar [1 ,3 ]
Al-Rubeaan, Khalid [4 ]
Luong, John H. T. [5 ,6 ]
Sheu, Fwu-Shan [1 ,3 ]
机构
[1] Natl Univ Singapore, NUSNNI NanoCore Inst, Singapore 117576, Singapore
[2] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore
[3] Natl Univ Singapore, Dept Elect & Comp Engn, Singapore 117576, Singapore
[4] King Saud Univ, Univ Diabet Ctr, Riyadh 11415, Saudi Arabia
[5] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
[6] Natl Univ Ireland Univ Coll Cork, Dept Chem, Cork, Ireland
关键词
LUNG EPITHELIAL-CELLS; IN-VITRO; PLASMID-DNA; SIDEWALL FUNCTIONALIZATION; PULMONARY TOXICITY; DISULFIDE BONDS; FIELD-EMISSION; LIVE CELLS; T-CELLS; SINGLE;
D O I
10.1021/tx100050h
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The unique structures and properties of carbon nanotubes (CNTs) have attracted extensive investigations for many applications, such as those in the field of biomedical materials and devices, biosensors, drug delivery, and tissue engineering. Anticipated large-scale productions for numerous diversified applications of CNTs might adversely affect the environment and human health. For successful applications in the biomedical field, the issue of interfacing between CNTs and mammalian cells in vitro needs to be addressed before in vivo studies can be carried out systematically. We review the important studies pertaining to the internalization of CNTs into the cells and the culturing of cells on the CNT-based scaffold or support materials. The review will focus on the description of a variety of factors affecting CNT cytotoxicity: type of CNTs, impurities. lengths of CNTs, aspect ratios, dispersion, chemical modification, and assaying methods of cytotoxicity.
引用
收藏
页码:1131 / 1147
页数:17
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