Fibulins: A versatile family of extracellular matrix proteins

被引：381

作者：

Timpl, R ^{[1
]}

Sasaki, T

Kostka, G

Chu, ML

机构：

[1] Max Planck Inst Biochem, Prot Chem Lab, D-82152 Martinsried, Germany

[2] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany

[3] Thomas Jefferson Univ, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1130

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibulins are a newly recognized family of extracellular matrix proteins. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures. New insights into their biological roles are now emerging from studies of transgenic mice and of some inherited human diseases.

引用

页码：479 / 489

页数：11

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