Mechanisms of resistance to xenobiotics in human therapy

被引：9

作者：

Saves, I

Masson, JM

机构：

[1] Inst Pharmacol & Biol Struct, F-31077 Toulouse, France

[2] Inst Natl Sci Appl, F-31077 Toulouse, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1998年 / 54卷 / 05期

关键词：

antibiotic; cytotoxic drugs; antipaludic drugs; anti-HIV-1; drugs; MDR; drug detoxification; drug inactivation; DNA repair;

D O I：

10.1007/s000180050170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Xenobiotic resistance is the major cause of failure in human therapies. Because of their serious clinical and economical consequences, resistance phenomena have been intensively studied in the case of antibacterial, anticancer, antipaludic and anti-human immunodeficiency virus-1 therapies. Beside pharmacological factors that can impede the action of the drugs, several cellular mechanisms of resistance have been described. Surprisingly, these mechanisms are conserved among bacteria, eucaryotic cells, parasites and viruses. The efficiency of drugs can be circumvented by alteration of the drug cellular concentration (altered influx, enhanced efflux or sequestration), detoxification, alteration of the drug target, nonactivation or inactivation of the drug, or by enhanced DNA repair.

引用

页码：405 / 426

页数：22

共 222 条

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