Regioselective synthesis of α,α-dialkylcyclopentanones from 1-hydroxycyclobutanecarboxylic acid or from O-protected cyclobutanone cyanohydrin.

被引：6

作者：

Estieu, K ^{[1
]}

Ollivier, J ^{[1
]}

Salaün, J ^{[1
]}

机构：

[1] Univ Paris Sud, Inst Chim Mol Orsay, Lab Carbocycles, CNRS, F-91405 Orsay, France

来源：

TETRAHEDRON | 1998年 / 54卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(98)00448-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-(1-Hydroxyalkyl)cylobutanols 4a-f, readily available either from 1-hydroxycyclobutane carboxylic acid or from O-protected cyclobutanone cyanohydrin, appeared the most suitable precursors for a regioselective synthesis of cyclopentanones alpha,alpha-disubstituted with various similar or different alkyl, alkenyl, aryl or cycloalkyl groups. The key steps consist of acid or Grignard reagent induced C-4 --> C-5 ring expansions. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8075 / 8090

页数：16

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