The cornified envelope: A model of cell death in the skin

被引：1328

作者：

Candi, E

Schmidt, R

Melino, G ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, Italy

[2] LOreal, Life Sci Res, Clichy, France

[3] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 04期

关键词：

D O I：

10.1038/nrm1619

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The epidermis functions as a barrier against the environment by means of several layers of terminally differentiated, dead keratinocytes-the cornified layer, which forms the endpoint of epidermal differentiation and death. The cornified envelope replaces the plasma membrane of differentiating keratinocytes and consists of keratins that are enclosed within an insoluble amalgam of proteins, which are crosslinked by transglutaminases and surrounded by a lipid envelope. New insights into the molecular mechanisms and the physiological endpoints of cornification are increasing our understanding of the pathological defects of this unique form of programmed cell death, which is associated with barrier malfunctions and ichthyosis.

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页码：328 / 340

页数：13

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