Circadian rhythm of objectively recorded hot flashes in postmenopausal breast cancer survivors

被引:41
作者
Carpenter, JS
Gautam, S
Freedman, RR
Andrykowski, M
机构
[1] Vanderbilt Univ, Sch Nursing, Nashville, TN 37240 USA
[2] Vanderbilt Univ, Dept Prevent Med, Div Biostat, Nashville, TN USA
[3] Wayne State Univ, Sch Med, Behav Med Lab, Detroit, MI USA
[4] Univ Kentucky, Coll Med, Dept Behav Sci, Lexington, KY 40536 USA
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2001年 / 8卷 / 03期
关键词
hot flashes; menopause; breast cancer; symptoms; circadian rhythm;
D O I
10.1097/00042192-200105000-00007
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Similar to the circadian rhythm of core body temperature, hot flashes have been found to exhibit a circadian rhythm in healthy, naturally postmenopausal women, with a peak in frequency at 18:25 h. However, to date, no studies have evaluated whether this same pattern is found among breast cancer survivors reporting hot flashes. Design: Daily hot flash frequencies were measured among 21 postmenopausal breast cancer survivors using validated 24-h sternal skin conductance monitoring. Results: Hot flashes were noted in all women, ranging in frequency from 1 to 30 per 24-h period. A majority of the sample (86%) experienced greater than or equal to 1 nighttime hot flash, with 48% exhibiting greater than or equal to 3 but less than or equal to 7 nighttime hot flashes. For the total sample, a modest circadian rhythm was noted with a peak in hot flash frequency occurring at 16:10 h. However, significant variability was observed across individual women, and, as a whole, breast cancer survivors demonstrated distorted to obliterated rhythms. Conclusions: Data suggest that hot flashes in postmenopausal breast cancer survivors do not follow the same circadian pattern as previously seen in healthy, naturally postmenopausal women. Findings have implications for (1) understanding the potential for sleep disturbances and fatigue in breast cancer survivors experiencing hot flashes, and (2) future research examining circadian rhythms of core body temperature and hot flashes in breast cancer survivors.
引用
收藏
页码:181 / 188
页数:8
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