Hypervariability in gene copy number for the glucose transporter genes in trypanosomes

被引:7
作者
Barrett, MP
Bringaud, F
Doua, F
Melville, SE
Baltz, T
机构
[1] UNIV BORDEAUX 2,LAB BIOL MOL & IMMUNOL PROTOZOAIRES PARASITES,URA 1637 CNRS,F-33076 BORDEAUX,FRANCE
[2] PROJET RECH CLIN TRYPANOSOMIASE,DALOA,COTE IVOIRE
[3] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND
关键词
African trypanosomes;
D O I
10.1111/j.1550-7408.1996.tb01400.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The copy number of the gene encoding the carrier protein responsible for the uptake of glucose in bloodstream form Trypanosoma brucei (THT1) was investigated in the genome of 55 different members of the subgenus Trypanozoon. The gene is present in multiple copies in tandem arrays on two homologous chromosomes in these organisms, and copy number varies both intra- and interspecifically. Variability is also apparent in the number of genes encoding a second hexose transporter (THT2) which is the only isoform expressed in procyclic organisms. Multiple copies of THT2 are conserved in representatives of the non-tsetse transmitted species, Trypanosoma evansi and Trypanosoma equiperdum.
引用
收藏
页码:244 / 249
页数:6
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