Metaplasticity in Human Cortex

被引:185
作者
Mueller-Dahlhaus, Florian [1 ,2 ]
Ziemann, Ulf [1 ,2 ]
机构
[1] Eberhard Karls Univ Tubingen, Dept Neurol & Stroke, Tubingen, Germany
[2] Univ Tubingen, Dept Neurol & Stroke, D-72076 Tubingen, Germany
关键词
metaplasticity; non-invasive brain stimulation; transcranial magnetic stimulation; transcranial direct current stimulation; motor learning; motor cortex; long-term potentiation; long-term depression; THETA-BURST STIMULATION; HUMAN MOTOR CORTEX; LONG-TERM POTENTIATION; TRANSCRANIAL MAGNETIC STIMULATION; NONINVASIVE BRAIN-STIMULATION; HOMEOSTATIC-LIKE PLASTICITY; DEPRESSION-LIKE PLASTICITY; CORTICAL PLASTICITY; SYNAPTIC PLASTICITY; ASSOCIATIVE PLASTICITY;
D O I
10.1177/1073858414526645
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Metaplasticity refers to the modification of plasticity induction (direction, magnitude, duration) by previous activity of the same postsynaptic neuron or neuronal network. In recent years evidence from animal studies has been accumulated that metaplasticity significantly contributes to network function and behavior. Here, we review the evidence for metaplasticity at the system level of the human cortex as investigated by non-invasive brain stimulation. These studies support the notion that metaplasticity is also operative in the human brain and is mostly homeostatic in nature, that is, keeping network activity within a physiological range. However, non-homeostatic metaplasticity has also been described, which can increase non-invasive brain stimulation-induced aftereffects on cortical excitability, or learning. Current evidence further suggests that aberrant metaplasticity may underlie some neurological and psychiatric diseases. Finally, first proof-of-principle studies show that the concept of metaplasticity can be harnessed for treatment of patients suffering from brain diseases.
引用
收藏
页码:185 / 202
页数:18
相关论文
共 135 条
[1]
Heterosynaptic metaplasticity in the hippocampus in vivo:: A BCM-like modifiable threshold for LTP [J].
Abraham, WC ;
Mason-Parker, SE ;
Bear, MF ;
Webb, S ;
Tate, WP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10924-10929
[2]
Metaplasticity: The plasticity of synaptic plasticity [J].
Abraham, WC ;
Bear, MF .
TRENDS IN NEUROSCIENCES, 1996, 19 (04) :126-130
[3]
Ackerley SJ, 2013, CLIN NEUROPHYSIOL, DOI [10.1016/j.clinph.2013.11.020, DOI 10.1016/J.CLINPH.2013.11.02020]
[4]
Combining Theta Burst Stimulation With Training After Subcortical Stroke [J].
Ackerley, Suzanne J. ;
Stinear, Cathy M. ;
Barber, P. Alan ;
Byblow, Winston D. .
STROKE, 2010, 41 (07) :1568-1572
[5]
IP3 Receptor Sensitization during In Vivo Amphetamine Experience Enhances NMDA Receptor Plasticity in Dopamine Neurons of the Ventral Tegmental Area [J].
Ahn, Kee-Chan ;
Bernier, Brian E. ;
Harnett, Mark T. ;
Morikawa, Hitoshi .
JOURNAL OF NEUROSCIENCE, 2010, 30 (19) :6689-6699
[6]
[Anonymous], CEREB CORTEX
[7]
[Anonymous], 2010, FRONT SYNAPTIC NEURO, DOI DOI 10.3389/FNSYN.2010.00034
[8]
Prior state of cortical activity influences subsequent practicing of a visuomotor coordination task [J].
Antal, Andrea ;
Begemeier, Silva ;
Nitsche, Michael A. ;
Paulus, Walter .
NEUROPSYCHOLOGIA, 2008, 46 (13) :3157-3161
[9]
Antal A, 2008, CEREB CORTEX, V18, P2701, DOI 10.1093/cercor/bhn032
[10]
Low-frequency rTMS promotes use-dependent motor plasticity in chronic stroke A randomized trial [J].
Avenanti, A. ;
Coccia, M. ;
Ladavas, E. ;
Provinciali, L. ;
Ceravolo, M. G. .
NEUROLOGY, 2012, 78 (04) :256-264