Antisense molecules and furanose conformations -: is it really that simple?

被引：48

作者：

Kværno, L

Wengel, J

机构：

[1] Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark

[2] Univ Copenhagen, Dept Chem, Ctr Synthet Bioorgan Chem, DK-2100 Copenhagen, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 16期

关键词：

D O I：

10.1039/b104605p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Selected nucleic acid mimics are discussed in the context of the antisense therapeutic strategy with focus on furanose conformation, RNA-binding affinity, and activation of the RNA-cleaving enzyme RNase H.

引用

页码：1419 / 1424

页数：6

共 74 条

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