Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions

被引：16

作者：

Dziekan, Thomas ^{[1
]}

Weissbach, Carmen ^{[1
]}

Voigt, Jan ^{[1
]}

Ebert, Bernd ^{[1
]}

Macdonald, Rainer ^{[1
]}

Bahner, Malte L. ^{[2
]}

Mahler, Marianne ^{[2
]}

Schirner, Michael ^{[2
]}

Berliner, Michael ^{[3
]}

Berliner, Birgitt ^{[4
]}

Osel, Jens ^{[5
]}

Osele, Ilka ^{[5
]}

机构：

[1] Phys Tech Bundesanstalt, D-10587 Berlin, Germany

[2] Mivenion GmbH, D-10115 Berlin, Germany

[3] HELIOS Klinikum Berlin Buch, Dept Phys Med & Rehabil, D-13125 Berlin, Germany

[4] HELIOS Res Ctr, D-10117 Berlin, Germany

[5] Helios Klinikum Bad Saarow, D-15526 Bad Saarow Pieskow, Germany

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2011年 / 16卷 / 07期

关键词：

rheumatoid arthritis; fluorescence imaging; two hand imager; clinical study; correlation function; image interpretation; computer aided diagnostics; INDOCYANINE-GREEN; TISSUE PERFUSION; BINDING; ICG;

D O I：

10.1117/1.3599958

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Fluorescence imaging using the dye indocyanine green as a contrast agent was investigated in a prospective clinical study for the detection of rheumatoid arthritis. Normalized variances of correlated time series of fluorescence intensities describing the bolus kinetics of the contrast agent in certain regions of interest were analyzed to differentiate healthy from inflamed finger joints. These values are determined using a robust, parameter-free algorithm. We found that the normalized variance of correlation functions improves the differentiation between healthy joints of volunteers and joints with rheumatoid arthritis of patients by about 10% compared to, e. g., ratios of areas under the curves of raw data. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3599958]

引用

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