Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis: differences in repeated cerebrospinal fluid examinations

被引：74

作者：

Bergamaschi, R

Tonietti, S

Franciotta, D

Candeloro, E

Tavazzi, E

Piccolo, G

Romani, A

机构：

[1] Univ Pavia, IRCCS C Mondino, Neurol Inst, Ctr Multiple Sclerosis, I-27100 Pavia, Italy

[2] Univ Pavia, IRCCS C Mondino, Neurol Inst, Lab Neuroimmunol, I-27100 Pavia, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2004年 / 10卷 / 01期

关键词：

cerebrospinal fluid; Devic's syndrome; multiple sclerosis; neuromyelitis optica; oligodonal bands;

D O I：

10.1191/1352458504ms988oa

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected in 399 of 411 patients (97%.) and never disappeared. In NMO, OBs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for the differentiation of NMO from MS.

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页码：2 / 4

页数：3

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