Amorphous no longer: the centrosome comes into focus

被引：114

作者：

Zimmerman, W ^{[1
]}

Sparks, CA ^{[1
]}

Doxsey, SJ ^{[1
]}

机构：

[1] Univ Massachusetts, Med Ctr, Program Mol Med, Worcester, MA 01605 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(99)80015-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly of proteins onto centrosomes and regulation of centrosome duplication and separation are being defined. Characterization of centrosome function, together with studies implicating centrosomes in tumorigenesis and demonstrating that centrosomes are highly organized, are beginning to bring into focus an organelle once viewed as an 'amorphous cloud'.

引用

页码：122 / 128

页数：7

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