CSF biomarkers in different phenotypes of Parkinson disease

被引：14

作者：

Jellinger, Kurt A.

机构：

来源：

JOURNAL OF NEURAL TRANSMISSION | 2012年 / 119卷 / 04期

关键词：

Parkinson disease; Clinical phenotypes; CSF biomarkers; Total-tau/A beta-42; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; CLINICAL-DIAGNOSIS; TAU; DEMENTIA; BETA;

D O I：

10.1007/s00702-011-0736-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

CSF biomarker studies were performed in 6 patients each with tremor-dominant (TD) and non-tremor-dominant (NT) Parkinson disease (PD) patients, 27 Alzheimer disease (AD) and 17 age-matched controls. In both NT-PD and AD patients total tau levels and the cortex tau/A beta-42 were significantly increased compared to both TD-PD patients and controls (p < 0.01). These data in a small cohort confirm previous studies, corroborating the opinion that CSF levels of tau protein and the index total-tau/A beta-42 may be potential markers of the severity of neurodegeneration in PD.

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页码：455 / 456

页数：2

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