Type 1 CD4+ T-cell help is required for induction of antipeptide multispecific cytotoxic T lymphocytes by a lipopeptidic vaccine in rhesus macaques

被引：48

作者：

Mortara, L

Gras-Masse, H

Rommens, C

Venet, A

Guillet, JG

Bourgault-Villada, I

机构：

[1] Univ Paris 05, Hop Cochin, INSERM,Inst Cochin Genet Mol, U445,Lab Immunol Pathol Infect & Tumorales, F-75014 Paris, France

[2] Univ Lille 2, Inst Pasteur Lille, Inst Biol Lille, CNRS,URA 1309,Lab Synth Struct & Fonct Biomol, F-59021 Lille, France

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 05期

关键词：

D O I：

10.1128/JVI.73.5.4447-4451.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have optimized the induction of antiviral cytotoxic T lymphocytes (CTL) in rhesus macaques by a lipopeptide vaccine containing seven peptides from simian immunodeficiency virus (SIV) Nef and Gag proteins and a strong T-helper peptide from tetanus toroid (TT) that is promiscuous in humans (peptide TT 830-846). Two of the eight immunized macaques showed T-helper (Th) cell proliferation and a specific synthesis of gamma interferon in response to TT 830-846 peptide. They also showed multispecific cytotoxic activity against three to five of the immunizing SN peptides. These results show the importance of a strong specific type 1 Th response for inducing a multispecific CTL response in vivo, which is essential for the development of an anti-human immunodeficiency virus vaccine.

引用

页码：4447 / 4451

页数：5

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