Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal

被引：110

作者：

Pérez, M

Cuadros, R

Smith, MA

Perry, G

Avila, J ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CSIC, E-28049 Madrid, Spain

[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

FEBS LETTERS | 2000年 / 486卷 / 03期

关键词：

tau assembly; phosphorylation; 4-hydroxy-2-nonenal; lipid peroxidation;

D O I：

10.1016/S0014-5793(00)02323-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A correlation between hyperphosphorylation of tau protein and its aberrant assembly into paired helical filaments has lead to suggestions that phosphorylation controls assembly, but lacked a mechanistic basic. In this work, we have found that phosphorylated, but not native, tau protein is able to form polymers after the reaction with 4-hydroxy-2-nonenal, a highly toxic product of lipid peroxidation. Phosphorylation of tau by both proline or non-proline directed kinases, mas able to assemble it into polymers. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：270 / 274

页数：5

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