DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks

被引：167

作者：

Bauer-Mehren, Anna ^{[1
]}

Rautschka, Michael ^{[1
]}

Sanz, Ferran ^{[1
]}

Furlong, Laura I. ^{[1
]}

机构：

[1] Univ Pompeu Fabra, DCEXS, Res Programme Biomed Informat GRIB IMIM, Barcelona 08003, Spain

来源：

BIOINFORMATICS | 2010年 / 26卷 / 22期

关键词：

D O I：

10.1093/bioinformatics/btq538

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

DisGeNET is a plugin for Cytoscape to query and analyze human gene-disease networks. DisGeNET allows user-friendly access to a new gene-disease database that we have developed by integrating data from several public sources. DisGeNET permits queries restricted to (i) the original data source, (ii) the association type, (iii) the disease class or (iv) specific gene(s)/disease(s). It represents gene-disease associations in terms of bipartite graphs and provides gene centric and disease centric views of the data. It assists the user in the interpretation and exploration of the genetic basis of human diseases by a variety of built-in functions. Moreover, DisGeNET permits multicolouring of nodes (genes/diseases) according to standard disease classification for expedient visualization.

引用

页码：2924 / 2926

页数：3

共 11 条

[1] PharmGKB: a logical home for knowledge relating genotype to drug response phenotype
Altman, Russ B.
[J]. NATURE GENETICS, 2007, 39 (04) : 426 - 426
[2] Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease
Botstein, D
Risch, N
[J]. NATURE GENETICS, 2003, 33 (Suppl 3) : 228 - 237
[3] Revisiting the Foundations of Network Analysis
Butts, Carter T.
[J]. SCIENCE, 2009, 325 (5939) : 414 - 416
[4] The human disease network
Goh, Kwang-Il
Cusick, Michael E.
Valle, David
Childs, Barton
Vidal, Marc
Barabasi, Albert-Laszlo
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (21) : 8685 - 8690
[5] Hamosh A, 2005, NUCLEIC ACIDS RES, V33, pD514
[6] Genome-wide association studies for common diseases and complex traits
Hirschhorn, JN
Daly, MJ
[J]. NATURE REVIEWS GENETICS, 2005, 6 (02) : 95 - 108
[7] Advances in translational bioinformatics: computational approaches for the hunting of disease genes
Kann, Maricel G.
[J]. BRIEFINGS IN BIOINFORMATICS, 2010, 11 (01) : 96 - 110
[8] The Comparative Toxicogenomics Database: A cross-species resource for building chemical-gene interaction networks
Mattingly, Carolyn J.
Rosenstein, Michael C.
Davis, Allan Peter
Colby, Glenn T.
Forrest, John N., Jr.
Boyer, James L.
[J]. TOXICOLOGICAL SCIENCES, 2006, 92 (02) : 587 - 595
[9] The structure and function of complex networks
Newman, MEJ
[J]. SIAM REVIEW, 2003, 45 (02) : 167 - 256
[10] Cytoscape: A software environment for integrated models of biomolecular interaction networks
Shannon, P
Markiel, A
Ozier, O
Baliga, NS
Wang, JT
Ramage, D
Amin, N
Schwikowski, B
Ideker, T
[J]. GENOME RESEARCH, 2003, 13 (11) : 2498 - 2504

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