Effects of a novel histamine H2-receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosa

被引:22
作者
Ichikawa, Takafumi
Ota, Hiroyoshi
Sugiyama, Atsushi
Maruta, Fukuto
Ikezawa, Tomoaki
Hotta, Kyoko
Ishihara, Kazuhiko
机构
[1] Kitasato Univ, Sch Med, Dept Biochem, Sagamihara, Kanagawa 2288555, Japan
[2] Shinshu Univ, Dept Biomed Lab Sci, Sch Hlth Sci, Sch Med, Matsumoto, Nagano, Japan
[3] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano, Japan
[4] Shinshu Univ, Sch Med, Dept Surg, Matsumoto, Nagano 390, Japan
[5] Kitasato Univ, Sch Med, Dept Internal Med, Sagamihara, Kanagawa 228, Japan
[6] Kitasato Univ, Sch Med, Sagamihara, Kanagawa 228, Japan
[7] Kitasato Univ, Grad Sch Med Sci, Dept Biochem, Sagamihara, Kanagawa 228, Japan
关键词
gastric mucin; human; immunohistochemistry; lafutidine; mucus;
D O I
10.1111/j.1440-1746.2006.04721.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aim: Lafutidine is a novel histamine H-2-receptor antagonist used primarily as an antisecretory agent in Japan. Previous human studies have not assessed its gastroprotective effects. The purpose of the present study was to determine the effects of lafutidine on the human gastric mucus layer using both histological and biochemical methods. Methods: Of the 14 patients scheduled for gastrectomy who consented to participate, seven were given 14 days of lafutidine 20 mg/day (lafutidine group) and the others received no medication (control group). The surface mucus gel layer in Carnoy-fixed tissue sections was examined immunohistochemically. Both the thickness of the mucus layer and its mucin content were measured in gastric corpus mucosa. Results: There was no detectable difference between the groups in the grade of gastritis or the immunohistochemical staining characteristics. The laminated structure of the surface mucus gel layer was retained after administration of lafutidine and it was thicker than the layer in the control group. The surface layer in the lafutidine group had three-fold more mucin than that in the control group. There was no difference between the two groups in the mucin content of the deep mucosa. Conclusion: Lafutidine, given at clinical dosages, not only inhibits acid secretion but also strengthens the mucus barrier of the human gastric mucosa.
引用
收藏
页码:1800 / 1805
页数:6
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