Protein kinases in the regulation of apoptosis in B-cell chronic lymphocytic leukemia

被引：16

作者：

Barragán, M

Campàs, C

Bellosillo, B

Gil, J

机构：

[1] Univ Barcelona, Dept Ciencias Fisiol 2, Unitat Bioquim, E-08907 Lhospitalet De Llobregat, Spain

[2] Univ Autonoma Barcelona, Hosp Mar, Serv Patol, E-08003 Barcelona, Spain

来源：

LEUKEMIA & LYMPHOMA | 2003年 / 44卷 / 11期

关键词：

B-CLL; apoptosis; protein kinases; survival; signal transduction;

D O I：

10.1080/1042819031000110964

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The involvement of several protein kinase pathways in the regulation of apoptosis and cell survival has been analyzed in a wide range of models. This article reviews current understanding of the protein kinases involved in the control of apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K) and nuclear factor-kappa B (NF-kappaB) play important roles in the survival of these leukemic cells. These survival pathways affect proteins involved in the control of apoptosis by altering their expression or function. The elucidation of the signal transduction network involved in the survival of B-CLL cells could provide novel pharmacological targets for the therapy of B-CLL.

引用

页码：1865 / 1870

页数：6

共 70 条

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