N-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms

被引：60

作者：

Torrejon, C. ^{[1
,2
]}

Jung, U. J. ^{[1
,2
]}

Deckelbaum, R. J. ^{[1
,2
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Inst Human Nutr, New York, NY 10032 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2007年 / 77卷 / 5-6期

关键词：

D O I：

10.1016/j.plefa.2007.10.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Cardiovascular disease and atherosclerosis are a leading cause of morbidity and mortality worldwide. Epidemiological studies and randomized control intervention trials have reported that n-3 fatty acids reduce cardiovascular events. A variety of biologic and molecular effects of n-3 fatty acids can modulate the mechanisms of development and progression of atherosclerosis. These include n-3 fatty acid effects on inflammation, cardiac excitability, platelet function, triglyceride blood levels, blood pressure and the stability of atheroma plaques. The molecular mechanisms are still not fully defined; but might involve changes in membrane fluidity, receptor responses and binding to intracellular receptors regulating gene transcription. Understanding and elucidating these mechanisms is important to development of future strategies for prevention and treatment of cardiovascular disease. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：319 / 326

页数：8

共 100 条

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DETECTION OF CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 AFTER LIVER-TRANSPLANTATION - EVIDENCE OF LOCAL RELEASE WITHIN THE LIVER DURING GRAFT-REJECTION [J].