In vitro activities of moxifloxacin and ether fluoroquinolones against Mycoplasma pneumoniae

被引：11

作者：

Hamamoto, K ^{[1
]}

Shimizu, T ^{[1
]}

Fujimoto, N ^{[1
]}

Zhang, Y ^{[1
]}

Arai, S ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Bacteriol, Kurume, Fukuoka 8300011, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期

关键词：

D O I：

10.1128/AAC.45.6.1908-1910.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A total of 105 isolates of Mycoplasma pneumoniae were evaluated for susceptibility to moxifloxacin, sparfloxacin, levofloxacin, and ciprofloxacin. Moxifloxacin, a newly synthesized compound, showed the greatest activity. The MICs and MBCs at which 50 and 90% of isolates were affected were 0.15 (MIC50 and MBC50) and 0.3 mug/ml (MIC90 and MBC90) respectively. The results indicate that moxifloxacin might be promising an antimycoplasmal agent.

引用

页码：1908 / 1910

页数：3

共 11 条

[1] ANGELA BB, 1997, ANTIMICROB AGENTS CH, V41, P1594
[2] EFFECTS OF NEW QUINOLONES ON MYCOPLASMA-PNEUMONIAE-INFECTED HAMSTERS
ARAI, S
GOHARA, Y
AKASHI, A
KUWANO, K
NISHIMOTO, M
YANO, T
OIZUMI, K
TAKEDA, K
YAMAGUCHI, T
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) : 287 - 292
[3] Pharmacodynamic properties of BAY 12-8039 on gram-positive and gram-negative organisms as demonstrated by studies of time-kill kinetics and postantibiotic effect
Boswell, FJ
Andrews, JM
Wise, R
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (06) : 1377 - 1379
[4] COMPARATIVE SUSCEPTIBILITY OF MYCOPLASMA-PNEUMONIAE TO ERYTHROMYCIN, CIPROFLOXACIN, AND LOMEFLOXACIN
CASSELL, GH
WAITES, KB
PATE, MS
CANUPP, KC
DUFFY, LB
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1989, 12 (05) : 433 - 435
[5] IN-VITRO AND IN-VIVO ACTIVITIES OF Q-35, A NEW FLUOROQUINOLONE, AGAINST MYCOPLASMA-PNEUMONIAE
GOHARA, Y
ARAI, S
AKASHI, A
KUWANO, K
TSENG, CC
MATSUBARA, S
MATUMOTO, M
FURUDERA, T
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (09) : 1826 - 1830
[6] Grayston JT, 1969, MYCOPLASMATALES L PH, P651
[7] Niitu Y, 1970, J Pediatr, V76, P438, DOI 10.1016/S0022-3476(70)80485-1
[8] METHOD FOR RELIABLE DETERMINATION OF MINIMAL LETHAL ANTIBIOTIC CONCENTRATIONS
PEARSON, RD
STEIGBIGEL, RT
DAVIS, HT
CHAPMAN, SW
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (05) : 699 - 708
[9] PETERSEN U, 1996, B SOC CHIM BELG, V105, P689
[10] TUOMANEN E, 1986, REV INFECT DIS S, V8, P279

← 1 2 →