The synthesis of taxoids from glucose

被引：9

作者：

Jenkins, PR

机构：

[1] Chemistry Department, Leicester University

来源：

PURE AND APPLIED CHEMISTRY | 1996年 / 68卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1351/pac199668030771

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of two model compounds of the anti-cancer natural product Taxol is described. The application of these results to the synthesis of chiral taxoids is outlined starting from the Robinson annulation of a protected glucose methyl ketone, further key stages are the Stork silylmethylene radical cyclisation and Vasella fragmentation to give a chiral synthon for the Taxol C-ring, a progress report on the further elaboration of this synthon is given.

引用

页码：771 / 774

页数：4

共 32 条

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