ELISA detection of clonazepam and 7-aminoclonazepam in whole blood and urine

被引：15

作者：

Elian, AA ^{[1
]}

机构：

[1] Commonwealth Massachusetts, Forens Toxicol Unit, State Police Crime Lab, Sudbury, MA 01776 USA

来源：

FORENSIC SCIENCE INTERNATIONAL | 2003年 / 134卷 / 01期

关键词：

clonazepam; 7-aminoclonazepam; oxazepam; cross-reactivity; ELISA;

D O I：

10.1016/S0379-0738(03)00099-9

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The ability of five commercially available enzyme-linked immunosorbent assay (ELISA) benzodiazepines to detect clonazepam and 7-aminoclonazepam in blood and urine was investigated. To determine the cross-reactivity of various ELISA assays, drug free blood and urine were fortified with clonazepam and 7-aminoflunitrazepam at concentrations of 1, 2.5, 5, 10, and 25 mug/dl. The cross-reactivity, with respect to oxazepam, for clonazepam was 16, 37, 80, 93, and 109% with Immunalysis, Diagnostix, Neogen, OraSure, and Cozart, respectively for 7-aminoclonazepam, none of the five ELISA assays showed any cross-reactivity above 10%. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：54 / 56

页数：3

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