Parkinson's disease: from causes to mechanisms

被引：43

作者：

Corti, O

Hampe, C

Darios, F

Ibanez, P

Ruberg, A

Brice, A

机构：

[1] Hop La Pitie Salpetriere, INSERM, U 289, F-75013 Paris, France

[2] Grp Hosp Pitie Salpetriere, Dept Genet Cytogenet & Embryol, F-75013 Paris, France

来源：

COMPTES RENDUS BIOLOGIES | 2005年 / 328卷 / 02期

关键词：

Parkinson's disease; environmental factors; familial Parkinsonian syndromes; ubiquitin-proteasome pathway; mitochondria;

D O I：

10.1016/j.crvi.2004.10.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Parkinson's disease (PD) is a common age-related, progressive neurodegenerative disease of unknown etiology. Environmental factors have long been suspected to participate in the pathogenesis of PD due to the existence of neurotoxins that preferentially damage the dopaminergic nigrostriatal pathway. In the past few years, novel insights into the degenerative process have been provided by the discovery of genes responsible for rare monogenic parkinsonian syndromes. Compelling evidence is accumulating, suggesting that the products of several of these genes can interact with environmental toxins and intervene in molecular pathways controlling the functional integrity of mitochondria. (C) 2004 Academie des sciences. Published by Elsevier SAS. All rights reserved.

引用

页码：131 / 142

页数：12

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