Pyrrolidine PNA-DNA chimeric oligonucleotides with extended backbone

被引：8

作者：

Kumar, VA ^{[1
]}

Meena ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

PNA-DNA chimera; PNA;

D O I：

10.1081/NCN-120022746

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cis-D-2-hydroxy-4-thymin-1-yl-pyrrolidine propionic acid unit is used to make PNA-DNA dimer block that is incorporated in DNA sequences at selected positions. Since the amide linkage is shorter than phosphodiester linkage, insertion of an extra atom in the backbone with amide linkage seems to be better accommodated for internucleotide distance-complementarity.

引用

页码：1101 / 1104

页数：4

共 2 条

[1] Pyrrolidine nucleic acids:: DNA/PNA oligomers with 2-hydroxy/aminomethyl-4-(thymin-1-yl)pyrrolidine-N-acetic acid [J].

Kumar, V ;

Pallan, PS ;

Meena ;

Ganesh, KN .

ORGANIC LETTERS, 2001, 3 (09) :1269-1272

[2] Studies of a chemically modified oligodeoxynucleotide containing a 5-atom amide backbone which exhibits improved binding to RNA [J].

Wilds, CJ ;

Minasov, G ;

Natt, F ;

von Matt, P ;

Altmann, KH ;

Egli, M .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2001, 20 (4-7) :991-994

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