Current strategies in gene therapy for ovarian cancer

被引：7

作者：

Barnes, MN ^{[1
]}

Pustilnik, TB ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Div Gynecol Oncol, Dept Obstet & Gynecol, Birmingham, AL 35249 USA

来源：

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY | 2001年 / 13卷 / 01期

关键词：

D O I：

10.1097/00001703-200102000-00007

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The application of gene therapy strategies for ovarian cancer has employed various viral and nonviral vectors. Thus far, adenovirus has been the most promising vehicle for gene replacement but the use of non DNA-based viruses is also being explored. Recent novel advances in gene therapy approaches include refinement of vector targeting and the use of site-specific promoters and conditionally replicative adenoviral vectors. Although several clinical trials have documented the relative safety of gene therapy in ovarian cancer patients, few significant clinical responses have been effected. However, advances in the field are occurring rapidly and this strategy does appear promising for the treatment of ovarian cancer. Curr Opin Obstet Gynecol 13:47-51. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：47 / 51

页数：5

共 31 条

[1] Ovarian cancer gene therapy: Repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model [J].

Al-Hendy, A ;

Magliocco, AM ;

Al-Tweigeri, T ;

Braileanu, G ;

Crellin, N ;

Li, H ;

Strong, T ;

Curiel, D ;

Chedrese, PJ .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2000, 182 (03) :553-559

[2] An adenovirus encoding proapoptotic Bax induces apoptosis and enhances the radiation effect in human ovarian cancer [J].

Arafat, WO ;

Gómez-Navarro, J ;

Xiang, JL ;

Barnes, MN ;

Mahasreshti, P ;

Alvarez, RD ;

Siegal, GP ;

Badib, AO ;

Buchsbaum, D ;

Curiel, DT ;

Stackhouse, MA .

MOLECULAR THERAPY, 2000, 1 (06) :545-554

[3]

BARNES M, 2000, GYNECOL ONCOL, V76, P259

[4] Gene therapy and ovarian cancer: A review [J].

Barnes, MN ;

Deshane, JS ;

Rosenfeld, M ;

Siegal, GP ;

Curiel, DT ;

Alvarez, RD .

OBSTETRICS AND GYNECOLOGY, 1997, 89 (01) :145-155

[5] Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab′γ)2 antibody [J].

Bartlett, JS ;

Kleinschmidt, J ;

Boucher, RC ;

Samulski, RJ .

NATURE BIOTECHNOLOGY, 1999, 17 (02) :181-186

[6] Adeno associated viral vectors for gene transfer and gene therapy [J].

Büeler, H .

BIOLOGICAL CHEMISTRY, 1999, 380 (06) :613-622

[7] Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells [J].

Chung, I ;

Schwartz, PE ;

Crystal, RG ;

Pizzorno, G ;

Leavitt, J ;

Deisseroth, AB .

CANCER GENE THERAPY, 1999, 6 (02) :99-106

[8]

Elkas John C., 1999, Gynecologic Oncology, V72, P456

[9]

Gu DL, 1999, CANCER RES, V59, P2608

[10] Adenovirus mediated p53 gene therapy has greater efficacy when combined with chemotherapy against human head and neck, ovarian, prostate, and breast cancer [J].

Gurnani, M ;

Lipari, P ;

Dell, J ;

Shi, B ;

Nielsen, LL .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1999, 44 (02) :143-151

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