Effects of a Structured Exercise Program on Insulin Resistance, Inflammatory Markers and Physical Fitness in Obese Korean Children

被引:38
作者
Chae, Hyun-Wook [2 ]
Kwon, Yu-Na [1 ]
Rhie, Young-Jun [3 ]
Kim, Ho-Seong [2 ]
Kim, Yu-Sik [1 ]
Paik, Il-Young [1 ]
Suh, Sang-Hoon [1 ]
Kim, Duk-Hee [2 ]
机构
[1] Yonsei Univ, Dept Phys Educ, Seoul 120749, South Korea
[2] Yonsei Univ, Dept Pediat, Seoul 120749, South Korea
[3] Korea Univ, Coll Med, Dept Pediat, Seoul 136705, South Korea
关键词
exercise; childhood obesity; insulin resistance; adiponectin; physical fitness; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR RISK-FACTORS; METABOLIC PARAMETERS; PEDIATRIC OBESITY; AEROBIC EXERCISE; CELL FUNCTION; WEIGHT-LOSS; BODY-FAT; ADOLESCENTS; ADIPONECTIN;
D O I
10.1515/jpem.2010.168
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thirty-eight obese Korean children (21 boys, 17 girls), whose ages were between 9 and 15, were divided into either the intervention group (19 obese children BMI>95P) or the age- and sex-matched obese control group The intervention group performed an intensive exercise program under the supervision of educated instructors for 12 weeks (90 minutes/day, two days/week) and received lifestyle modification counseling using food diaries and phone calls The control group participated in conventional counseling at an out-patient clinic The intervention group appeared to have more improvement of body weight, body composition, serum lipid profiles and high-sensitivity C-reactive protein (hs-CRP) levels (P < 0 05) but without changes in serum adiponectin level HOMA-IR decreased from 23 to 13 in the intervention group Maximal oxygen consumption (VO2 max) and other physical fitness parameters were significantly improved after the intervention program (P < 005)
引用
收藏
页码:1065 / 1072
页数:8
相关论文
共 35 条
[1]   Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: A controlled, randomized study in obese adolescents [J].
Balagopal, P ;
George, D ;
Yarandi, H ;
Funanage, V ;
Bayne, E .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (11) :6192-6197
[2]   Determinants of early atherosclerosis in obese children and adolescents [J].
Beauloye, Veronique ;
Zech, Francis ;
Mong, Hiep Tran Thi ;
Clapuyt, Philippe ;
Maes, Marc ;
Brichard, Sonia M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (08) :3025-3032
[3]   Elevated C-reactive protein constitutes an independent predictor of advanced carotid plaques in dyslipidemic subjects [J].
Blackburn, R ;
Giral, P ;
Bruckert, E ;
André, JM ;
Gonbert, S ;
Bernard, M ;
Chapman, MJ ;
Turpin, G .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (12) :1962-1968
[4]   Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: Associations with metabolic parameters and insulin resistance and regulation by physical training [J].
Bluher, Matthias ;
Bullen, John W., Jr. ;
Lee, Jennifer H. ;
Kralisch, Susan ;
Fasshauer, Mathias ;
Kloting, Nora ;
Niebauer, Josef ;
Schon, Michael R. ;
Williams, Catherine J. ;
Mantzoros, Christos S. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (06) :2310-2316
[5]   Prevalence and trends of a metabolic syndrome phenotype adolescents, 1999-2000 [J].
Duncan, GE ;
Li, SM ;
Zhou, XH .
DIABETES CARE, 2004, 27 (10) :2438-2443
[6]  
Epstein LH, 1998, PEDIATRICS, V101, P554
[7]   Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women - A randomized trial [J].
Esposito, K ;
Pontillo, A ;
Di Palo, C ;
Giugliano, G ;
Masella, M ;
Marfella, R ;
Giugliano, D .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (14) :1799-1804
[8]   The relation of overweight to cardiovascular risk factors among children and adolescents: The Bogalusa heart study [J].
Freedman, DS ;
Dietz, WH ;
Srinivasan, SR ;
Berenson, GS .
PEDIATRICS, 1999, 103 (06) :1175-1182
[9]   Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence [J].
Guo, SS ;
Wu, W ;
Chumlea, WC ;
Roche, AF .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (03) :653-658
[10]   Adiponectin is not altered with exercise training despite enhanced insulin action [J].
Hulver, MW ;
Zheng, DH ;
Tanner, CJ ;
Houmard, JA ;
Kraus, WE ;
Slentz, CA ;
Sinha, MK ;
Pories, WJ ;
MacDonald, KG ;
Dohm, GL .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 283 (04) :E861-E865