Neurogenic genes and vertebrate neurogenesis

被引:232
作者
Lewis, J
机构
[1] ICRF Developmental Biology Unit, Department of Zoology, University of Oxford, Oxford OX1 3PS, South Parks Road
关键词
D O I
10.1016/S0959-4388(96)80002-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neurogenic genes of the Delta-Notch signalling pathway mediate lateral inhibition - a mechanism that controls cell commitment in many tissues and serves in the developing nervous system to single out cells for a neural fate. Recent work has revealed the outlines of the signal transduction pathway from Notch to the nucleus, has clarified the mechanisms by which lateral inhibition causes adjacent cells to become different, and has shown that vertebrates use essentially the same lateral inhibition machinery as flies and worms to regulate neurogenesis.
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页码:3 / 10
页数:8
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