Endothelial nitric oxide synthase:: a determinant of TNFα production by human monocytes/macrophages

被引：29

作者：

Mühl, H ^{[1
]}

Pfeilschifter, J ^{[1
]}

机构：

[1] Univ Frankfurt Klinikum, Pharmazentrum Frankfurt, D-60590 Frankfurt, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 310卷 / 03期

关键词：

endothelial nitric oxide synthase; inducible nitric oxide synthase; inflammation; monocytes; macrophages; tumor necrosis factor-alpha; N-6-monomethyl-L-arginine;

D O I：

10.1016/j.bbrc.2003.09.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFalpha production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：677 / 680

页数：4

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