Expression of c-kit protooncogene in human hepatocellular carcinoma

被引：29

作者：

Chung, CY

Yeh, KT

Hsu, NC

Chang, JHM

Lin, JT

Horng, HC

Chang, CS

机构：

[1] Changhua Christian Hosp, Dept Internal Med, Div Hematol Oncol, Changhua 500, Taiwan

[2] Changhua Christian Hosp, Dept Med Educ & Res, Changhua, Taiwan

[3] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan

来源：

CANCER LETTERS | 2005年 / 217卷 / 02期

关键词：

c-kit; human hepatocellular carcinoma; receptor tyrosine kinase;

D O I：

10.1016/j.canlet.2004.06.045

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of the c-kit protooncogene in human hepatocellular carcinoma (HCC) was investigated. Immunohistochemical staining (IHC) and RT-PCR were employed to examine the protein and mRNA expression of c-kit protooncogene, respectively. IHC results demonstrated that 22 of 86 (25.6%) HCC tissue sections expressed c-kit protein. The c-kit mRNA transcript was further confirmed in all 22 IHC c-kit positive HCC tissue samples by RT-PCR. Moreover, the relationship between c-kit expression in HCC and prognosis of patients was statistically analyzed and a correlation was established. The group of patients whose HCC specimens showed positive c-kit staining exhibited better survival as compared to those patients with negative c-kit expression (p=0.021). These results suggest that c-kit expression may be a good prognostic indicator for HCC. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：231 / 236

页数：6

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