Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells

被引：42

作者：

Fang, LB ^{[1
]}

Fehse, B ^{[1
]}

Engel, M ^{[1
]}

Zander, A ^{[1
]}

Kröger, N ^{[1
]}

机构：

[1] Univ Hamburg, Hosp Eppendorf, Dept Bone Marrow Transplantat, D-20246 Hamburg, Germany

来源：

TRANSPLANTATION | 2005年 / 79卷 / 03期

关键词：

dendritic cells; GVHD; allogeneic stem-cell transplantation; antithymocyte globulin;

D O I：

10.1097/01.TP.0000150210.77543.1B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigate the in vivo and ex vivo effect of rabbit antithymocyte globulin (ATG) on myeloid dendritic cells (MDCs) and plasmacytoid dendritic cells (PDCs). After incubation with ATG and complement, the mean number of MDCs and PDCs decreases from 3,168 to 739 X 10(3)/mL (P=0.004) and from 5,314 to 790 X 10(3)/mL (P=0.01), respectively. In vivo ATG given as part of the conditioning regimen before allogeneic stem-cell transplantation induces a stronger reduction of circulating MDCs and PDCs than chemotherapy alone (reduction: 100% vs. 78%-98%). These data show that ATG induces depletion of circulating MDCs and PDCs, which might be in addition to the T-cell depletion a further mechanism to reduce graft-versus-host disease after allogeneic stem-cell transplantation.

引用

页码：369 / 371

页数：3

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