A T2*magnetic resonance imaging study of pancreatic iron overload in thalassemia major

被引：80

作者：

Au, Wing-Yan ^{[1
]}

Lam, Wynnie Wai-Man ^{[3
]}

Chu, Winnie ^{[3
]}

Tam, Sidney ^{[4
]}

Wong, Wai-Keng ^{[4
]}

Liang, Raymond ^{[1
]}

Ha, Shau-Yin ^{[2
]}

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China

[2] Univ Hong Kong, Queen Mary Hosp, Dept Pediat & Adolescent Med, Hong Kong, Peoples R China

[3] Univ Hong Kong, Prince Wales Hosp, Dept Diagnost Radiol, Hong Kong, Peoples R China

[4] Queen Mary Hosp, Clin Biochem Unit, Hong Kong, Peoples R China

来源：

HAEMATOLOGICA | 2007年 / 93卷 / 01期

关键词：

magnetic resonance; thalassemia;

D O I：

10.3324/haematol.11768

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (beta cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels.This suggested that improved chelation may improve beta cell reserve and prevent pancreatic atrophy.

引用

页码：116 / 119

页数：4

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