Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

被引：2148

作者：

Su, Shuo ^{[1
,2
]}

Wong, Gary ^{[3
,4
,5
]}

Shi, Weifeng ^{[6
]}

Liu, Jun ^{[5
,7
]}

Lai, Alexander C. K. ^{[8
]}

Zhou, Jiyong ^{[1
,2
]}

Liu, Wenjun ^{[4
,5
]}

Bi, Yuhai ^{[3
,4
,5
]}

Gao, George F. ^{[3
,4
,5
,7
,9
,10
]}

机构：

[1] Nanjing Agr Univ, Inst Immunol, Engn Lab Anim Immun Jiangsu Prov, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China

[3] Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen, Peoples R China

[4] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

[5] Chinese Acad Sci, CAS Ctr Influenza Res & Early Warning CASCIRE, Beijing, Peoples R China

[6] Taishan Med Coll, Inst Pathogen Biol, Tai An, Shandong, Peoples R China

[7] Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

[8] Kentucky State Univ, Frankfort, KY USA

[9] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

[10] Univ Chinese Acad Sci, Chinese Acad Sci, Sch Med, Beijing, Peoples R China

来源：

TRENDS IN MICROBIOLOGY | 2016年 / 24卷 / 06期

基金：

加拿大健康研究院; 中国国家自然科学基金;

关键词：

RESPIRATORY SYNDROME CORONAVIRUS; INTESTINAL CELL-INTERACTIONS; MOUSE HEPATITIS-VIRUS; SARS CORONAVIRUS; TRANSMISSIBLE GASTROENTERITIS; CLINICAL-FEATURES; DROMEDARY CAMELS; BAT CORONAVIRUS; NL63; INFECTION; MERS-COV;

D O I：

10.1016/j.tim.2016.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Human coronaviruses (HCoVs) were first described in the 1960s for patients with the common cold. Since then, more HCoVs have been discovered, including those that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), two pathogens that, upon infection, can cause fatal respiratory disease in humans. It was recently discovered that dromedary camels in Saudi Arabia harbor three different HCoV species, including a dominant MERS HCoV lineage that was responsible for the outbreaks in the Middle East and South Korea during 2015. In this review we aim to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans.

引用

页码：490 / 502

页数：13

共 95 条

[1]

Abdul-Rasool Sahar, 2010, Open Virol J, V4, P76, DOI 10.2174/1874357901004010076

[2]

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients [J].