Nickel-catalyzed addition of pyridine-N-oxides across alkynes

被引：240

作者：

Kanyiva, Kyalo Stephen ^{[1
]}

Nakao, Yoshiaki ^{[1
]}

Hiyama, Tamejiro ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 46期

关键词：

alkynes; C-C coupling; C-H activation; nickel; pyridine-N-oxides;

D O I：

10.1002/anie.200703758

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An alternative to pyridine: Pyridine-N-oxides undergo direct C-H activation and add across alkynes under mild nickel catalysis to afford (E)-2-alkenylpyridine-N-oxides in modest to good yields with high selectivity. Subsequent deoxygenation and deoxygenative functionalization proceed smoothly to give a wide variety of 2-substituted pyridines. PCyp 3 = tricyclopentylphosphine, cod = cyclooctadiene. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8872 / 8874

页数：3

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